Logan
Living with CRS for 9 years
“All the treatments I was trying weren’t helping.”
Enduring Every Day
Why So Many Are Suffering with CRS
Millions of people suffer with CRS every day. For the majority of patients who have run out of effective or viable therapies, we believe more can be done to address treatment gaps.
The voices of CRS
Diane
Living with CRS for 30+ years
“It’s a burden to have chronic symptoms all the time.”
Larry
Living with CRS for 6 years
“CRS is a fight – it’s a struggle. I feel like what I’m doing now is just a temporary fix.”
Identifying The Gap
What’s Missing from Current Treatments
Chronic rhinosinusitis, or CRS, is a debilitating inflammatory disease that causes nasal congestion, facial pain and pressure, nasal discharge and loss of sense of smell for approximately 14 million people in the United States.
Patients try multiple approaches to seek CRS symptom relief, including over-the-counter remedies, sinus rinses, and prescribed steroids delivered via nasal spray or oral pills. These approaches are not effective in relieving CRS symptoms for half of the 8 million patients who use them.
4 MILLION CRS PATIENTS FAIL MEDICAL MANAGEMENT
AND HAVE VERY LIMITED TREATMENT OPTIONS
Medical management for CRS does not work for half who try it. Only a small portion turn to sinus surgery.
Patients still suffering with CRS are faced with a treatment gap.
Inside The Lines
A Physician’s Perspective on Current Treatment Challenges
“Every day, I see the significant impact that chronic rhinosinusitis (CRS) has on people living with this disease. CRS makes patients feel miserable for years. Patients and doctors are ready for new treatment options that provide long-term relief, improving daily life for people with CRS.”
Zachary M. Soler, MD, MSc
Division of Rhinology and Sinus Surgery, Medical University of South Carolina
Lyra Therapeutics Clinical Trials in CRS
Are you interested in participating in a clinical trial for a new treatment for CRS?
Facing The Facts
The Physical + Emotional Toll of CRS
Nearly
1 IN 8
adults in the U.S. suffer from chronic rhinosinusitis. It is usually diagnosed in young or middle-aged adults.
CRS occurs when the sinuses inside the nose and head are swollen and inflamed for at least
3 MONTHS
CRS differs from acute sinusitis, which is a temporary viral or bacterial infection of the sinuses.
CRS can have a significant negative impact on quality of life; it has been
compared to living with COPD and congestive heart failure.
Cardinal Symptoms of CRS
Nasal obstruction and congestion
Facial pain and pressure
Nasal discharge
Loss of smell
Additional CRS Symptoms
Sleep disturbances
Ear pain
Headache
Aching in jaw or teeth
Cough
Sore throat
Bad breath
Fatigue
Depression
Anxiety
A typical CRS sufferer
Misses 18 workdays per year.
Managing CRS can include a burdensome daily routine and if disrupted, symptoms can spiral out of control.
CRS is the
MAIN DRIVER OF ANTIBIOTIC USE AMONG ADULTS.
SOURCES
Battacharrya. Ann Otol Rhinol Laryngol, 2011; Jul;120(7):423-7
Jang et al. Otolaryngol Head Neck Surg, 2018
Baguley et al. Int Forum Allergy Rhinol, 2014;4(7):525-32
Soler ZM, Wittenberg E, Schlosser RJ, Mace JC, Smith TL. Health state utility values in patients undergoing endoscopic sinus surgery. Laryngoscope. 2011;121(12):2672-2678.
Orlandi RR, Kingdom TT, Smith TL, et al. International consensus statement on allergy and rhinology: rhinosinusitis 2021. Int Forum Allergy Rhinol. Mar 2021;11(3):213-739.
Mayo Clinic, https://www.mayoclinic.org/diseases-conditions/chronic-sinusitis/symptoms-causes/syc-20351661
Tan BK et al. Am J Respir Crit Care Med, 2013;188(11):1275–7
Rudmik L, Smith TL, Schlosser RJ, Hwang PH, Mace JC, Soler ZM. Productivity costs in patients with refractory chronic rhinosinusitis. Laryngoscope. Sep 2014;124(9):2007-12.
